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Extracellular NMN must be converted to NR by the 5-nucleotidase CD73 before being taken up intracellularly and then converted back to NMN by nicotinamide riboside kinase 1 26

Lactobacillus plantarum in turn produces beneficial metabolites, strengthens gut epithelial defenses, enhance immune tolerance, and contributes to the restoration of thyroid immune homeostasis (Talebi et al., 2020

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